LEADING SCIENCE IN HAIR LOSS TREATMENTS
Daniel Alain Life Science, the parent company behind the proven science of INTACT, strives to be at the forefront of R & D in the field of hair loss and works closely with world-renowned dermatologists and scientists. As a result, our research and findings are published in highly regarded, peer-reviewed medical journals on a regular basis. A partial list of published studies can be found below. This relentless pursuit of scientific knowledge is the fuel that drives our product development engine.
The Science & Development Behind INTACT
INTACT Root Securing Complex was developed over a span of five years by a team of leading dermatologists and scientists focused on hair loss solutions. What started as a path to better understanding hair fall and excessive hair shedding in women, has since led to a breakthrough solution to hair loss for women.
Styling without shedding: Novel topical formula reduces hair shedding by contracting the arrector pili muscle.
McCoy J, Goren A, Kovacevic M, Situm M, Stanimirovic A, Shapiro J, Sinclair R.
Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12575. Epub 2017 Nov 28. PubMed PMID: 29193553.
Goren A, Shapiro J, Sinclair R, Kovacevic M, McCoy J.
Dermatol Ther. 2016 May;29(3):160-3
Goren A, McCoy J, Kovacevic M, Situm M, Chitalia J, Dhurat R, Naccarato T, Lotti T.
J Biol Regul Homeost Agents. (Accepted June 11, 2018)
Goren A, Shapiro J, Naccarato T, Situm M, Kovacevic M, Lonky N, Lotti T, McCoy J.
2017 Oct-Dec;31(4):1013-1016. PubMed PMID: 29254307.
Mechanism of action of minoxidil in the treatment of androgenetic alopecia is likely mediated by mitochondrial adenosine triphosphate synthase-induced stem cell differentiation.
Goren A, Naccarato T, Situm M, Kovacevic M, Lotti T, McCoy J.
2017 Oct-Dec;31(4):1049-1053. PubMed PMID: 29254313.
Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil.
McCoy J, Goren A, Kovacevic M, Shapiro J.
2016 Oct-Dec;30(4):1153-1155. PubMed PMID: 28078868.
Doppler laser imaging predicts response to topical minoxidil in the treatment of female pattern hair loss.
McCoy J, Kovacevic M, Situm M, Stanimirovic A, Bolanca Z, Goren A.
J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):131-4.
Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z, Pietrzak A, Lotti T.
Dermatol Ther. 2015 Jan-Feb;28(1):13-6.
Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil in the treatment of female Androgenetic Alopecia.
Roberts J, Desai N, McCoy J, Goren A.
Dermatol Ther. 2014 Jul-Aug;27(4):252-4.
Acute telogen effluvium onset event is associated with the presence of female Androgenetic Alopecia: potential therapeutic implications.
Perez-Mora N, Goren A, Velasco C, Bermudez F.
Dermatol Ther. 2014 May-Jun;27(3):159-62.
Goren A, Castano JA, McCoy J, Bermudez F, Lotti T.
Dermatol Ther. 2014 May-Jun;27(3):171-3.
Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with Androgenetic Alopecia nediated by epigenetics.
Keene S, Goren A.
Dermatol Ther. 2011 Mar-Apr;24(2):296-300.