INTACT - ROOT SECURING COMPLEX

LEADING SCIENCE IN HAIR LOSS TREATMENTS

Daniel Alain Life Science, the parent company behind the proven science of INTACT, strives to be at the forefront of R & D in the field of hair loss and works closely with world-renowned dermatologists and scientists. As a result, our research and findings are published in highly regarded, peer-reviewed medical journals on a regular basis. A partial list of published studies can be found below. This relentless pursuit of scientific knowledge is the fuel that drives our product development engine.

The Science & Development Behind INTACT

INTACT Root Securing Complex was developed over a span of five years by a team of leading dermatologists and scientists focused on hair loss solutions. What started as a path to better understanding hair fall and excessive hair shedding in women, has since led to a breakthrough solution to hair loss for women.

2018 Jan

Styling without shedding: Novel topical formula reduces hair shedding by contracting the arrector pili muscle.

McCoy J, Goren A, Kovacevic M, Situm M, Stanimirovic A, Shapiro J, Sinclair R.
Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12575. Epub 2017 Nov 28. PubMed PMID: 29193553.

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2016 Oct

Prevalence of hair shedding among women.

Kovacevic M, Goren A, Shapiro J, Sinclair R, Lonky NM, Situm M, Bulat V, Bolanca Z, McCoy J.
Dermatol Ther. 2016 Oct 6. doi: 10.1111/dth.12415.

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2016 May

α1 -AR Agonist induced piloerection protects against the development of Traction Alopecia.

Goren A, Shapiro J, Sinclair R, Kovacevic M, McCoy J.
Dermatol Ther. 2016 May;29(3):160-3
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2018 Jun

The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity.

Goren A, McCoy J, Kovacevic M, Situm M, Chitalia J, Dhurat R, Naccarato T, Lotti T.
J Biol Regul Homeost Agents. (Accepted June 11, 2018)

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2017 Oct-Dec

Social selection favours offspring prone to the development of androgenetic alopecia.

Goren A, Shapiro J, Naccarato T, Situm M, Kovacevic M, Lonky N, Lotti T, McCoy J.
2017 Oct-Dec;31(4):1013-1016. PubMed PMID: 29254307.
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2017 Oct-Dec

Mechanism of action of minoxidil in the treatment of androgenetic alopecia is likely mediated by mitochondrial adenosine triphosphate synthase-induced stem cell differentiation.

Goren A, Naccarato T, Situm M, Kovacevic M, Lotti T, McCoy J.
2017 Oct-Dec;31(4):1049-1053. PubMed PMID: 29254313.

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2016 Oct-Dec

Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil.

McCoy J, Goren A, Kovacevic M, Shapiro J.
2016 Oct-Dec;30(4):1153-1155. PubMed PMID: 28078868.
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2016 Jan-Mar

Doppler laser imaging predicts response to topical minoxidil in the treatment of female pattern hair loss.

McCoy J, Kovacevic M, Situm M, Stanimirovic A, Bolanca Z, Goren A.
J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):131-4.

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2015 Jan-Feb

Clinical utility and validity of minoxidil response testing in Androgenetic Alopecia.

Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z, Pietrzak A, Lotti T.
Dermatol Ther. 2015 Jan-Feb;28(1):13-6.

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2014 May-Jun

Acute telogen effluvium onset event is associated with the presence of female Androgenetic Alopecia: potential therapeutic implications.

Perez-Mora N, Goren A, Velasco C, Bermudez F.
Dermatol Ther. 2014 May-Jun;27(3):159-62.
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2014 May-Jun

Novel enzymatic assay predicts minoxidil response in the treatment of Androgenetic Alopecia.

Goren A, Castano JA, McCoy J, Bermudez F, Lotti T.
Dermatol Ther. 2014 May-Jun;27(3):171-3.

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